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Classification of IgG1and IgG2isotypes

Authors
Journal
Immunochemistry
0019-2791
Publisher
Elsevier
Publication Date
Volume
13
Issue
3
Identifiers
DOI: 10.1016/0019-2791(76)90227-5

Abstract

Abstract Sequences have been compared for the C H3 domain of the IgG1 and IgG2 isotypes of guinea-pig and mouse. The degree of homology (about 60%) lies between that of human classes (about 30%) and that of human IgG subclasses (> 90%). Human (and rabbit) IgG—including all its subclasses—is more IgG1-like than IgG2-like when compared with mouse or guinea-pig isotypes. It is suggested that the nomenclature reflect the fact that the homology of human IgG subclasses is very much greater than that of mouse and guinea-pig isotypes.

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