Affordable Access

Publisher Website

Regulation of hippocampal neurogenesis in adulthood

Authors
Journal
Biological Psychiatry
0006-3223
Publisher
Elsevier
Publication Date
Volume
48
Issue
8
Identifiers
DOI: 10.1016/s0006-3223(00)01021-0
Keywords
  • Molecular And Cellular Hypotheses Of Antidepressant Action

Abstract

Abstract A substantial number of new granule neurons are produced in the dentate gyrus in adulthood in a variety of mammalian species, including humans. Numerous studies have demonstrated that the production and survival of new hippocampal neurons can be enhanced or diminished by hormones and experience. Steroid hormones of the ovaries and adrenal glands have been shown to modulate the production of immature neurons by affecting the proliferation of granule cell precursors. Aversive experiences have been demonstrated to decrease the production of immature granule cells, whereas enriching experiences, including learning, have been shown to enhance the survival of new hippocampal cells. These studies indicate that adult-generated neurons represent a unique form of structural plasticity that can be regulated by the environment, and furthermore suggest that new neurons play an important role in hippocampal function.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Regulation of hippocampal neurogenesis in adulthoo...

on Biological Psychiatry Oct 15, 2000

Molecular regulation of adult hippocampal neurogen...

on Journal of stem cells & regene... 2007

Wnt signaling in the regulation of adult hippocamp...

on Frontiers in Cellular Neurosci... Jan 01, 2013
More articles like this..