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Comparison of the effects of the immunosuppressive agents FK 506 and cyclosporin a on rat kidney mitochondria

Authors
Journal
Biochemical Pharmacology
0006-2952
Publisher
Elsevier
Publication Date
Volume
46
Issue
5
Identifiers
DOI: 10.1016/0006-2952(93)90491-e

Abstract

Abstract Interactions of FK 506 with renal cortical mitochondria have been investigated by measuring respiration, ATP net uptake and Ca 2+/P iinduced swelling. Both FK 506 and cyclosporin A (CsA) inhibit the succinate-supported state 3 and uncoupled respiration and are without effect on the glutamate/ malate-supported state 3 and uncoupled respiration. FK 506, like CsA, inhibits net uptake of ATP, but, in contrast to CsA, is without effect on Ca 2+/P i-induced swelling.

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