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FAMILIAL ISLET-CELL ADENOMATOSIS

Authors
Journal
The Lancet
0140-6736
Publisher
Elsevier
Publication Date
Volume
310
Issue
8035
Identifiers
DOI: 10.1016/s0140-6736(77)90609-2
Disciplines
  • Medicine

Abstract

Abstract Familial multiple adenoma of pancreatic beta-cells is described for the first time. The occurrence of diabetes mellitus in different members of the family raises the possibility of a common genetic origin for the multiple islet-cell adenomas and the diabetic trait. The evidence suggests that this gene is autosomal and dominant, that it is not linked with the HLA antigens, and that it causes an abnormal sensitivity of the beta-cells, which become hyperplastic or hypofunctional.

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