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Pharmacological modulation of gabaergic transmission in cultured cerebellar neurons

Authors
Journal
Neuropharmacology
0028-3908
Publisher
Elsevier
Publication Date
Volume
25
Issue
2
Identifiers
DOI: 10.1016/0028-3908(86)90043-2

Abstract

Abstract GABA activates specific ion channels in post-natal cerebellar neurons in primary culture generating Cl − currents that can be recorded with the whole-cell patch-clamp technique. Evoked and spontaneous GABA-mediated synaptic activity can be recorded from cells kept in culture for a few days. Benzodiazepine and beta-carboline derivatives which bind with high affinity to the domains for allosteric regulation of GABA receptors facilitated and inhibited directly applied GABA responses and synaptically evoked Cl − currents recorded under voltage-clamp.

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