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Severe mitochondrial anomaly in dystrophic mouse skeletal muscle

Authors
Journal
Neuroscience Letters
0304-3940
Publisher
Elsevier
Publication Date
Volume
90
Identifiers
DOI: 10.1016/0304-3940(88)90802-6
Keywords
  • Mitochondrial Anomaly
  • Dystrophy
  • Skeletal Muscle
  • Mouse
Disciplines
  • Biology

Abstract

Abstract Mitochondrial fractions were isolated from skeletal muscle of control (C57 BL 6J dy/+) and dystrophic (C57 BL 6J dy/dy) mice, and enzymatic activities (cytochrome c oxidase, rotenone-insensitive NADH cytochrome c reductase) were determined. After electrophoretic separation, calcium-binding proteins were identified. An important anomaly was observed in the mitochondria of dystrophic muscle, i.e., a considerable reduction of a specific calcium-binding protein (61,000 Da mol. wt.).

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