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Protein sequencing: Thermal conversion of thiazolinone derivatives of amino acids to thiohydantoins

Authors
Journal
Analytical Biochemistry
0003-2697
Publisher
Elsevier
Publication Date
Volume
66
Issue
2
Identifiers
DOI: 10.1016/0003-2697(75)90607-7

Abstract

Abstract A method for converting thiazolinone derivatives of amino acids to their thiohydantoin derivatives is described. Because this method proceeds through a thermally induced intramolecular rearrangement, the amide groups of glutamine and asparagine are not hydrolyzed. Special procedures are not required for the recovery of the derivatives of arginine and histidine. Finally, the thermal method is more rapid than the conventional aqueous conversion procedure.

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