Affordable Access

Publisher Website

Expression of platelet-derived endothelial cell growth factor (PD-ECGF) and its mRNA in uterine endometrial cancers

Authors
Journal
Cancer Letters
0304-3835
Publisher
Elsevier
Publication Date
Volume
130
Identifiers
DOI: 10.1016/s0304-3835(98)00129-3
Keywords
  • Pd-Ecgf
  • Neovascularization
  • Endometrial Cancer
Disciplines
  • Biology
  • Medicine

Abstract

Abstract To determine the potential of growth, invasion and metastasis of uterine endometrial cancer cells associated with neovascularization, the expressions of platelet-derived endothelial cell growth factor (PD-ECGF) and its mRNA in uterine endometrial cancers and in normal uterine endometria as controls were determined and the relationship between their expressions and histological grades, grades of myometrial invasion and clinical stages of uterine endometrial cancers was analyzed. The levels of PD-ECGF were significantly higher in uterine endometrial cancers of well-differentiated grade (G1) with invasion to ≤1/2 myometrium (B) and of stage I than in those of moderately and poorly differentiated grades (G2 and G3, respectively) limited to endometrium (A) and with invasion to >1/2 myometrium (C) and of stages II and III/IV and in normal uterine endometria. There was no significant difference in the levels between uterine endometrial cancers of G2 and G3, A and C, or stages II and III/IV and normal uterine endometria. Therefore, the active availability of PD-ECGF might contribute to the acceleration of angiogenic activity in the early process of invasion of well-differentiated uterine endometrial cancers.

There are no comments yet on this publication. Be the first to share your thoughts.