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Lipophilicity of a series of 1,2-benzisothiazol-3(2H)-ones determined by reversed-phase thin-layer chromatography

Authors
Journal
Journal of Chromatography A
0021-9673
Publisher
Elsevier
Publication Date
Volume
952
Identifiers
DOI: 10.1016/s0021-9673(02)00089-4
Keywords
  • 1
  • 2-Benzisothiazol-3(2H)-Ones

Abstract

Abstract The lipophilicity ( R Mo) and specific hydrophobic surface area of seven 1,2-benzisothiazol-3(2H)-ones have been determined by reversed-phase TLC and the effect of different mobile-phase modifiers (acetone, acetonitrile, methanol) on the retention has been studied. The linear correlations between the volume fraction of the organic solvent and the R M values over a limited range were established for each solute with high values of correlation coefficients (>0.99). The influence of solvent pH on R M values was investigated.

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