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Examination of bioenergetic function in the inner mitochondrial membrane peptidase 2-like (Immp2l) mutant mice

Authors
Journal
Redox Biology
2213-2317
Publisher
Elsevier
Identifiers
DOI: 10.1016/j.redox.2014.08.006
Keywords
  • Immp2L
  • Cytochrome C1
  • Gpd2
  • Complex Iii
  • Mitochondrial Respiration
Disciplines
  • Biology

Abstract

Abstract Inner mitochondrial membrane peptidase 2-like (IMMP2L) protein is a mitochondrial inner membrane peptidase that cleaves the signal peptide sequences of cytochrome c1 (CYC1) and mitochondrial glycerol phosphate dehydrogenase (GPD2). Immp2l mutant mice show infertility and early signs of aging. It is unclear whether mitochondrial respiratory deficiency underlies this phenotype. Here we show that the intermediate forms of GPD2 and CYC1 have normal expression levels and enzymatic function in Immp2l mutants. Mitochondrial respiration is not diminished in isolated mitochondria and cells from mutant mice. Our data suggest that respiratory deficiency is not the cause of the observed Immp2l mutant phenotypes.

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