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Prostacyclin and blood glucose levels in humans and rabbits

Authors
Journal
Prostaglandins & Other Lipid Mediators
0090-6980
Publisher
Elsevier
Publication Date
Volume
21
Issue
1
Identifiers
DOI: 10.1016/0090-6980(81)90201-x
Disciplines
  • Biology
  • Medicine

Abstract

Abstract In patients with peripheral vascular disease and in healthy rabbits, infusion of PGI 2 but not of 6-keto PGF 1α induced a rise in blood glucose level and a pathological deviation in glucose tolerance test. In experiments in vitro , the increased concentrations of glucose produced dose-dependent inhibition of PGI 2 release from isolated rat aortic rings. The link between PGI 2 and carbohydrate metabolism is discussed.

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