Affordable Access

Severity of alcohol withdrawal symptoms depends on developmental stage of Long–Evans rats

Pharmacology Biochemistry and Behavior
Publication Date
DOI: 10.1016/j.pbb.2007.12.002
  • Adolescence
  • Alcohol Consumption Alcohol Dependency
  • Alcohol Metabolism
  • Alcohol Withdrawal
  • Intoxication
  • Long–Evans Rats


Abstract To investigate alcohol dependency and the potential role of age of initial alcohol consumption, Long–Evans (LE) rats were fed an ethanol-containing liquid diet starting at postnatal (P) ages (days): P23–27 (juvenile), P35–45 (adolescent) or P65–97 (young adult). Severity of subsequent withdrawal symptoms was dependent on age when consumption began and on duration of alcohol consumption. Frequency of withdrawal seizures was highest for rats starting consumption as juveniles, intermediate for adolescents and lowest for adults. Normalized to body weight, alcohol consumption was significantly higher for adolescent and juvenile rats than for adults. Sprague–Dawley rats that began alcohol consumption as adolescents (P35) had a level of alcohol consumption identical to that of the adolescent LE rats but showed much lower frequency of withdrawal seizures when tested after 2, 3 and 5 weeks of alcohol consumption. Based on several indicators, the capacity of the juveniles to metabolize ethanol is equal to or exceeds that of adults. Recoveries from a single dose of ethanol (2.5 g ethanol/kg body weight) were faster for juvenile LE rats than adults. The rate of decline in blood ethanol concentration was identical for juvenile and adult rats while the corrected ethanol elimination rate was higher for juveniles. The primary isozyme of alcohol dehydrogenase (ADH) in rat liver, ADH-3, had a similar Km and higher activity in liver preparations from juveniles. In conclusion, LE rats beginning alcohol consumption as juveniles or adolescents develop a severe alcohol withdrawal syndrome that may not be attributed entirely to higher levels of consumption and was not explained by any obvious deficiencies in metabolism.

There are no comments yet on this publication. Be the first to share your thoughts.


Seen <100 times

More articles like this

Withdrawal symptoms in a long-term model of volunt...

on Pharmacology Biochemistry and... May 2000

Withdrawal Symptoms in a Long-Term Model of Volunt...

on Pharmacology Biochemistry and... Jan 01, 2000

Gestational alcoholism and fetal zinc accretion in...

on Journal of the American Colleg... June 1990

Prolactin serum levels during alcohol withdrawal a...

on Alcoholism Clinical and Experi... February 2011
More articles like this..