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Tadpoles, drugs and toxicities

Authors
Publisher
Elsevier Ltd
Publication Date
Volume
4
Issue
6
Identifiers
DOI: 10.1016/0968-0004(79)90447-x
Disciplines
  • Biology

Abstract

Abstract The theory of Brodie and his collaborators that the non-specific drug metabolizing enzymes were developed in terrestrial species of animals essentially to enable them to convert lipid-soluble exogenous compounds to more readily excretable polar derivatives has withstood the test of time. The theory has come into focus again because of the foreseeable consequences of contaminating the global environment with more and more unmetabolizable lipid-soluble compounds.

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