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The p Value of HPIV3-Mediated Autophagy Inhibition

Authors
Journal
Cell Host & Microbe
1931-3128
Publisher
Elsevier
Publication Date
Volume
15
Issue
5
Identifiers
DOI: 10.1016/j.chom.2014.04.014

Abstract

Autophagy, a vesicular pathway involving the lysosomal degradation of cytosolic contents, is frequently hijacked by intracellular pathogens to optimize their infectivity. In this issue of Cell Host & Microbe, Ding et al. (2014) show that human parainfluenza virus exploits autophagy by targeting SNAREs and preventing the SNAP29-Stx17 interaction, an otherwise crucial event in autophagosome-lysosome fusion.

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