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Predictions of which diastereoisomeric salt precipitates during an optical resolution via diastereoisomeric salt formation

Authors
Journal
Tetrahedron
0040-4020
Publisher
Elsevier
Publication Date
Volume
50
Issue
23
Identifiers
DOI: 10.1016/s0040-4020(01)81342-9

Abstract

Abstract The DSC data of sixteen conglomerate forming diastereoisomeric salt pairs were analysed. It was demonstrated that during optical resolution via fractional crystallization of diastereoisomeric salt pairs always that diastereoisomeric salt precipitates which has the higher melting point. When one of the salts is amorphous that remains in the mother liquor. If one of the diastereoisomeric salt crystallizes with solvate that will precipitate during optical resolutions.

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