Affordable Access

Effect of Inflammation upon the Growth of Transplantable Neoplasms as Demonstrated by the “Double Granuloma-Pouch” Technique

British Journal of Cancer
Nature Publishing Group
Publication Date
  • Articles
  • Medicine


550 EFFECT OF INFLAMMATION UPON THE GROWTH OF TRANS- PLANTABLE NEOPLASMS AS DEMONSTRATED BY THE "DOUBLE GRANULOMA-POUCH" TECHNIQUE H. SELYE From the Institut de MSeecine et de Chirurgie experimentales Universite de Montreal, Montreal, Canada Received for publication October 1, 1957 THE effect of inflammation upon the growth of neoplasms has long been the subject of controversy. Some investigators claim that transplantable tumours grow better in inflamed than in normal tissue (Rous, Murphy and Tytler, 1912; Jones and Rous, 1914; Jones, 1926; Carrel, 1925), while others maintain that inflammation does not influence neoplastic growth (Molomut, Spain, Kreisler and Warshaw, 1955), or actually inhibits it (Kubo, 1924; Busch, 1952; Williams, 1944). According to Kubo (1930), chronic inflammation enhances, while acute inflam- matory reactions inhibit the development of neoplasms. Yet, the acute inflam- matory reaction that ensues following mechanical trauma to tissue allegedly enhances the growth of subsequent topical tumour implants (Zahl and Nowak, 1949), while chronically repeated mechanical irritation may cause tumours to involute (Aschoff quoted by Hirschfeld, 1919). The "granuloma-pouch technique" (Selye, 1953)-in which a suspension of transplantable tumour tissue is injected into a subcutaneous air-pouch-appears to be particularly well suited for the study of this problem. It permits the inoculation of transplants into a regularly formed ellipsoid connective-tissue-sac which may or may not have been previously transformed into an inflammatory granuloma by pretreatment with an irritant (e.g., croton oil). Recently, Hewitt (1956) used the granuloma-pouch technique for his investiga- tions on this subject. He came to the conclusion that, in the mouse, the growth of Sarcoma 37 remains uninfluenced by the acute inflammatory hyperaemia that is induced by formic-acid-pretreatment of the site of inoculation. In considering this problem, it must be kept in mind that an inflammation caused by irri

There are no comments yet on this publication. Be the first to share your thoughts.


Seen <100 times