Affordable Access

Publisher Website

Interleukin 2 induces rapid phosphorylation of cellular proteins in murine T-lymphocytes

Authors
Journal
FEBS Letters
0014-5793
Publisher
Wiley Blackwell (John Wiley & Sons)
Publication Date
Volume
198
Issue
1
Identifiers
DOI: 10.1016/0014-5793(86)81179-6
Keywords
  • Interleukin 2
  • Protein Phosphorylation
  • T-Lymphocyte
  • Dna Synthesis
  • Cell Proliferation
Disciplines
  • Biology

Abstract

Abstract When quiescent murine T-lymphocyte cells were stimulated by the addition of interleukin 2 (IL-2), they reinitiated DNA synthesis after a lag period of 5 h. Under these conditions, rapid but transient phosphorylation of two cellular proteins with M r, values of 27000 and 26000 was detected; maximal phosphorylation occurred within 10–15 min after the addition of IL-2. The protein of M r, 27 000 contained phosphoserine, while the protein of M r 26000 contained phosphothreonine.

There are no comments yet on this publication. Be the first to share your thoughts.