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Neuronal activity during development: permissive or instructive?

Authors
Journal
Current Opinion in Neurobiology
0959-4388
Publisher
Elsevier
Publication Date
Volume
9
Issue
1
Identifiers
DOI: 10.1016/s0959-4388(99)80011-7
Disciplines
  • Mathematics

Abstract

Abstract Experimental studies over the past year have shown that neural activity has a range of effects on the development of neural pathways. Although activity appears unimportant for establishing many aspects of the gross morphology and topology of the brain, there are many cases where the presence of neural activity is essential for the formation of a mature system of neural connections; in some instances, the pattern of neural activity actually orchestrates the final arrangement of neural connections.

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