This study identifies and evaluates determinants of employees’ job and residential mobility. It examines mobility of fulltime employees in selected sectors in 2003/2004, using register data provided by Statistics Netherlands. We estimate a multinomial model of job and residential change. The results illustrate that individuals decide upon changing jobs and/or relocating by taking into account the strength of their family- and job-related ties. We also find that the prevalence of internal versus external career opportunities impedes job changes. While a high salary facilitates relocation, our findings regarding the effect of salary on interfirm mobility were inconclusive. A long commuting distance encourages (simultaneous) job and housing mobility, while being situated in the municipality of a large city encourages employees to either change jobs, or to relocate.