Affordable Access

Publisher Website

On the significance of Surfactant Protein-A within the human lungs

Authors
Journal
Diagnostic Pathology
1746-1596
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Volume
4
Issue
1
Identifiers
DOI: 10.1186/1746-1596-4-8
Keywords
  • Review
Disciplines
  • Biology
  • Chemistry
  • Medicine

Abstract

Surfactant Protein-A (SP-A) is the most prominent among four proteins in the pulmonary surfactant-system. SP-A is expressed by alveolar epithelial cells type II as well as by a portion of non small cell lung carcinomas (NSCLC). The expression of SP-A is complexly regulated on the transcriptional and the chromosomal level. SP-A is a major player in the pulmonary cytokine-network and moreover has been described to act in the pulmonary host defense. By the use of cell culture or animal models the functional properties have been repeatedly shown in many aspects, often bearing surprising properties which strongly indicate the physiological importance of SP-A. To date SP-A is recognized as a molecule essential for pulmonary development, structure and function. An upcoming number of reports deals with the role of SP-A for pulmonary pathology. This article gives an overview about the state of knowledge on SP-A focused in applications for human pulmonary disorders and points out the importance for pathology-orientated research approaches using immunohistochemistry or in situ hybridization as promising methods to further elucidate the role of this molecule in adult lung diseases.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Surfactant protein B in type II pneumocytes and in...

on American journal of respirator... April 2004

[Expression of pulmonary surfactant-associated pro...

on Di 1 jun yi da xue xue bao = A... March 2005

Clearance of surfactant protein A from rabbit lung...

on American journal of respirator... January 1995

Clearance of surfactant protein B from rabbit lung...

on The American journal of physio... April 1995
More articles like this..