Affordable Access

Publisher Website

Efficient synthesis of tertiary amines from secondary amines

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
47
Issue
28
Identifiers
DOI: 10.1016/j.tetlet.2006.05.038
Disciplines
  • Chemistry
  • Mathematics

Abstract

Abstract Reliable N-alkylations of secondary amines have been developed. By using DIAD and TPP (or PS-TPP) a variety of secondary amines can be converted to the corresponding tertiary amines in good to excellent yields with diverse alkylhalides; no formation of quaternary amine salts are observed. These protocols are amenable to combinatorial chemistry libraries, and are also useful for the syntheses of secondary amines by an acid lysis of the cleavable tertiary amino resins.

There are no comments yet on this publication. Be the first to share your thoughts.