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Brain dopamine receptors and sleep in the rat: Effects of stimulation and blockade

Authors
Journal
European Journal of Pharmacology
0014-2999
Publisher
Elsevier
Publication Date
Volume
38
Issue
2
Identifiers
DOI: 10.1016/0014-2999(76)90340-x
Keywords
  • Dopamine Receptors
  • Paradoxical Sleep
  • Apomorphine
  • Rat Sleep
  • Spiroperidol
  • Chlorpromazine

Abstract

Abstract A high dose of apomorphine, a stimulator of brain dopamine receptors, caused a reduction in total sleep, intermediate sleep and a delayed appearance of paradoxical sleep. With a lower dose, a small and not significant trend toward an increase of paradoxical sleep was observed. Spiroperidol, considered as a specific blocker of dopamine receptors, produced a dose-dependent increase of total sleep and a decrease of paradoxical sleep. Chlorpromazine induced a different effect, that is clear enhancement of paradoxical sleep. Taken together, these results indicate that an activation of dopamine systems in the brain is partly involved not only in behavioral activation, but also in corticl activation of waking and paradoxical sleep. The effect of chlorpromazine on paradoxical sleep cannot be attributed to the antidopaminergic properties of this drug.

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