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Modeling and Simulation Workbench for NONMEM: Tutorial on Pirana, PsN, and Xpose

Authors
Journal
CPT Pharmacometrics & Systems Pharmacology
2163-8306
Publisher
Nature Publishing Group
Publication Date
Volume
2
Issue
6
Identifiers
DOI: 10.1038/psp.2013.24
Source
Legacy
Keywords
  • Tutorial
Disciplines
  • Medicine
  • Pharmacology

Abstract

Several software tools are available that facilitate the use of the NONMEM software and extend its functionality. This tutorial shows how three commonly used and freely available tools, Pirana, PsN, and Xpose, form a tightly integrated workbench for modeling and simulation with NONMEM. During the tutorial, we provide some guidance on what diagnostics we consider most useful in pharmacokinetic model development and how to construct them using these tools.

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