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GABA in the PNS: Demonstration in enteric neurons

Authors
Journal
Brain Research Bulletin
0361-9230
Publisher
Elsevier
Publication Date
Volume
16
Issue
3
Identifiers
DOI: 10.1016/0361-9230(86)90066-3
Keywords
  • Gamma-Aminobutyric Acid
  • Avian
  • Enteric Nervous System
  • Immunocytochemistry
  • High Pressure Liquid Chromatography

Abstract

Abstract The hypothesis that gamma-aminobutyric acid (GABA) is a peripheral neurotransmitter was tested by determining whether GABA is present in enteric neurons. GABA was detected in the quail gut using high pressure liquid chromatography. GABA-like immunoreactivity was found in both enteric neural plexuses. Only a few neuronal perikarya, but many fibers were stained in each. GABA-immunoreactive neurons survived for over a week in vitro; therefore, they must be intrinsic to the bowel. These and earlier observations indicate that GABA is a peripheral (enteric) as well as a central neurotransmitter.

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