Affordable Access

Publisher Website

Epithelial Cell Shape: Cadherins and Small GTPases

Authors
Journal
Experimental Cell Research
0014-4827
Publisher
Elsevier
Publication Date
Volume
261
Issue
1
Identifiers
DOI: 10.1006/excr.2000.5050
Disciplines
  • Biology

Abstract

Abstract Cadherins are cell–cell adhesion receptors that are essential for the establishment of the epithelial cell shape and maintenance of the differentiated epithelial phenotype. In order to show efficient adhesion, cadherin receptors require an association with actin filaments and the activity of RHO proteins. The RHO family of small GTPases is primarily involved in the reorganization of the cytoskeleton. In different cell types, each member of the family can induce specific types of organization of actin filaments: stress fibers (Rho), lamellae/ruffles (Rac), or filopodia (Cdc42). This review focuses on how the function of small GTPases may impinge on the regulation of cadherin-dependent adhesion. In particular, it discusses the impact that the above cytoskeletal structures induced by RHO proteins have on the development of epithelial morphology. Finally, the participation of small GTPase-interacting proteins is considered during the remodeling of cell shape that follows cell–cell contact formation.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Epithelial cell shape: cadherins and small GTPases...

on Experimental Cell Research Nov 25, 2000

Epithelial cell shape and Rho small GTPases.

on Novartis Foundation symposium 2005

Small Rho GTPases in the control of cell shape and...

on Cellular and Molecular Life Sc... May 2014
More articles like this..