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Cardiovascular adverse reactions from NSAIDs are more than COX-2 inhibition alone 'The gun must be loaded for COX-2 inhibitors to pull the trigger and cause cardiovascular toxicity'

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This editorial refers to ‘Association of myocardial infarctions with COX-2 inhibition may be related to immunomodulation towards a Th1 response resulting in atheromatous plaque instability: an evidence-based interpretation’, by Ireneusz T. Padol et al.

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