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Effect of chlorpromazine and haloperidol on negative contrast

Authors
Journal
Pharmacology Biochemistry and Behavior
0091-3057
Publisher
Elsevier
Publication Date
Volume
42
Issue
1
Identifiers
DOI: 10.1016/0091-3057(92)90455-o
Keywords
  • Chlorpromazine
  • Haloperidol
  • Flurazepam
  • Neuroleptic
  • Sucrose
  • Contrast

Abstract

Abstract Rats shifted from 32 to 4% sucrose consume substantially less of the 4% solution than animals that have not had prior experience with the 32% sucrose. This negative contrast effect was not substantially influenced by chlorpromazine (1, 3, and 5 mg/kg) or haloperidol (0.1, 0.5, and 1.0 mg/kg). Haloperidol decreased overall lick frequency, but this decrease occurred proportionately in shifted and unshifted rats, leaving contrast intact. The benzodiazepine flurazepam (5, 10, and 20 mg/kg), included as a positive control, reduced contrast at the two highest doses. The results suggest thav neuroleptics do not disrupt consummatory contrast and that dopaminergic antagonists may not influence reward relativity.

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