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Alkylation of succinates: Synthesis of Ro 32–3555

Authors
Journal
Bioorganic & Medicinal Chemistry Letters
0960-894X
Publisher
Elsevier
Publication Date
Volume
8
Issue
2
Identifiers
DOI: 10.1016/s0960-894x(97)10179-2

Abstract

Abstract A short synthesis, based on a succinate acylation-alkylation-decarboxylation approach, of the clinical compound Ro 32–3555 is reported. The nature of the selectivity in the mono-alkylation of succinates was examined under varying enolization conditions and in the presence of chaotropic additives.

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