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The double-edge sword effect of anti-CD73 cancer therapy

Authors
Journal
OncoImmunology
2162-4011
Publisher
Landes Bioscience
Publication Date
Volume
1
Issue
2
Identifiers
DOI: 10.4161/onci.1.2.18101
Keywords
  • Author'S View

Abstract

We and others have identified CD73 as a new cancer target. I hereafter discuss that targeted blockade of CD73 has the effect of a “double-edge sword,” able on the one hand to rescue endogenous adaptive anti-tumor immune responses, and on the other hand, inhibit the metastatic potential of tumor cells.

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