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A facile synthesis of 4- and 6-chloromethyl-1H-indole-2-carboxylates: replacement of a sulfonic acid functionality by chlorine

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
44
Issue
12
Identifiers
DOI: 10.1016/s0040-4039(03)00327-7
Keywords
  • Fischer Synthesis
  • 4-(Chloromethyl)Indoles
  • 6-(Chloromethyl)Indoles
  • Desulfination

Abstract

Abstract Valuable new synthetic intermediates, 4- or 6-chloromethyl-1 H-indole-2-carboxylates, were prepared by the elimination of SO 2 from 2-ethoxycarbonyl-1 H-indole-4- or 6-methanesulfonic acids, respectively, which are easily accessible by Fischer-type indolization.

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