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Characterizing T-cell epitopes in vaccine candidates

Authors
Journal
Immunology Today
0167-5699
Publisher
Elsevier
Publication Date
Volume
10
Issue
12
Identifiers
DOI: 10.1016/0167-5699(89)90037-6

Abstract

Abstract T-cell clones can be used to test in vitro whether synthetic peptides associate with major histocompatibility complex (MHC) antigens — a necessary condition for the peptides to be immunogenic. Generally, the T-cell clones have been obtained from immune donors, but J.R.L. Pink and F. Sinigaglia argue here that non-immune, human leukocyte antigen (HLA)-typed donors are a useful source of clones and antigen-presenting cells that can be used to assay systematically peptide—MHC associations.

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