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Five Theses on the Blocked University

University of Zagreb, faculty of Law, Study centre for Social Work; [email protected]
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  • Biology
  • Design


Siddiqui.vp In recent years, indole derivatives have acquired conspicuous significance due to their wide spectrum of biological activities. The anticonvulsant drug design is based on the presumption (1) that for the activity in maximal electroshock seizure (MES) evalua- tion, at least one phenyl or similar aromatic group in close proximity to a two electron donor atom is required. For activity in pentylenetetrazole (PTZ) evaluation, an alkyl group close to a two electron donor atom is needed. Several five-membered aromatic systems such as triazoles, oxadiazoles and thiadia- zoles having three heteroatoms at symmetrical positions have been evaluated for their anticonvulsant activity (2, 3). New 3-aryl/alkylimino-indol-2-ones were synthesized and screened for their anticonvulsant and anti-inflammatory activities. Compounds having 1-naphthyl and 4-chlorophenyl substituents were most potent compounds of the series (4). A series of 3-aryl/alkylimino-indol-2-ones were synthesized and screened for anti- 445 Acta Pharm. 58 (2008) 445–454 Original research paper 10.2478/v10007-008-0025-0 Synthesis, anticonvulsant and toxicity evaluation of 2-(1H-indol-3-yl)acetyl-N-(substituted phenyl)hydrazine carbothioamides and their related heterocyclic derivatives NADEEM SIDDIQUI* M. SHAMSHER ALAM WAQUAR AHSAN Department of Pharmaceutical Chemistry Faculty of Pharmacy, Jamia Hamdard (Hamdard University) New Delhi-110062, India Accepted September 25, 2008 A series of new 5-(1H-indol-3-yl)methyl-4-(substituted aryl)-2,4-dihydro-3H-1,2,4-triazole-3-thiones (4a-g), 5-(1H- -indol-3-yl)methyl-N-(substituted aryl)-1,3,4-oxadiazol- -2-amines (5a-g) and 5-(1H-indol-3-yl)methyl-N-(substi- tuted aryl)-1,3,4-thiadiazol-2-amines (6a-g) were prepared by treating 2-(1H-indol-3-yl)acetyl-N-(substituted phen- yl)hydrazine carbothioamides (3a-g) with suitable rea- gents. All the newly synthesized compounds were scree- ned for their anticonvulsant activity in the MES model and were compared with the standard

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