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Enriched Selection of Dominant Mutations: Histidine Operator Mutations

Authors
Publication Date
Source
PMC
Keywords
  • Genetics And Molecular Biology
Disciplines
  • Biology

Abstract

In the course of selection of bacteria with derepressed levels of histidine biosynthetic enzymes, it was found that when mutagen-treated cells were spread on a selective medium without allowing intervening growth to occur, the frequency of operator mutants obtained was dramatically increased. This may be useful as a general enrichment for operator or other dominant mutations.

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