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N-Terminal sequence similarities between components of the multicatalytic proteinase complex

Authors
Journal
FEBS Letters
0014-5793
Publisher
Wiley Blackwell (John Wiley & Sons)
Publication Date
Volume
262
Issue
2
Identifiers
DOI: 10.1016/0014-5793(90)80220-d
Keywords
  • Multicatalytic Proteinase
  • Protease
  • Gene Family
  • (Rat Liver)
Disciplines
  • Biology

Abstract

Abstract The multicatalytic proteinase complex is a high molecular weight nonlysosomal proteinase which is composed of many different types of subunit. As part of a study of the possible relationships between subunits, polypeptides derived from the multicatalytic proteinase from rat liver have been subjected to N-tenninal amino acid sequence analysis. Although several of the subunits are blocked at their N-termini, sequences have been obtained for 7 of the polypeptides. Each of the 7 sequences is unique but they show considerable sequence similarity, suggesting that the proteins are encoded by members of the same gene family.

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