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Expression and release of adhesion molecules by human acute myelogenous leukemia blasts

Authors
Journal
Leukemia Research
0145-2126
Publisher
Elsevier
Publication Date
Volume
23
Issue
2
Identifiers
DOI: 10.1016/s0145-2126(98)00156-8
Keywords
  • Acute Myelogenous Leukemia
  • Intercellular Adhesion Molecule 1
  • L-Selectin

Abstract

Abstract The expression and release of adhesion molecules by acute myelogenous leukemia (AML) blasts was investigated in vitro. For most patients AML blasts expressed relatively low levels of membrane-bound l-selectin and Intercellular adhesion molecule 1 (ICAM-1), but their soluble forms were detected in the supernatants for the majority of patients when AML blasts were cultured in vitro. These in vitro levels of s l-selectin and sICAM-1 were considerably lower than the normal serum levels. Divergent and relatively small alterations in s l-selectin and sICAM-1 levels were usually observed when exogenous growth factors were present during AML blast culture, whereas increased s l-selectin levels were observed after coculture of AML blasts and normal leucocytes. e- and p-selectin were neither expressed nor released by AML blasts. We conclude that AML blasts are a source of soluble adhesion molecules.

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