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Magic ferritin: A novel chemotherapeutic encapsulation bullet

Authors
Journal
Journal of Magnetism and Magnetic Materials
0304-8853
Publisher
Elsevier
Publication Date
Volume
293
Issue
1
Identifiers
DOI: 10.1016/j.jmmm.2005.01.066
Keywords
  • Apoferritin
  • Doxorubicin
  • Encapsulation
  • Ferritin
  • Chemotherapy

Abstract

Abstract The dissociation of apoferritin into subunits at pH 2 followed by its reformation at pH 7.4 in the presence of doxorubicin–HCl gives rise to a solution containing five doxorubicin–HCl molecules trapped within the apoferritin. This is the first report showing that ferritin can encapsulate an anti-cancer drug into its cavity.

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