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Pyridine Nucleotide Synthesis in Host Tissues of Tumour-Bearing Animals

British Journal of Cancer
Nature Publishing Group
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482 PYRIDINE NUCLEOTIDE SYNTHESIS IN HOST TISSUES OF TUMOUR-BEARING ANIMALS M. V. NARIURKAR, U. S. KUMTA AND M. B. SAHASRABUDHE From the Biology Division, Atomic Energy Establishment, Indian Cancer Research Centre, Parel, Bombay 12, India Received for publication May 27, 1957 THE parasitic nature of tumour cells has attracted considerable attention and several reports have appeared on the tumour-host relationship (Gurnani, Kumta and Sahasrabudhe, 1956; Greenles and LePage, 1955; Mider, 1951 ; Greenstein, 1954; Greenberg and Sassenrath, 1955). In this context the rapid turnover of nucleic acids (Tyner, Heidelberger and LePage, 1953; Barnum and Huseby, 1950; Griffin, Davies and Tifft, 1952; Hulbert and Potter, 1952) and the low levels of pyridine nucleotides (PN) (Carruthers and Suntzeff, 1954; Strength, Ringler and Nelson, 1954; Jedekin and Weinhouse, 1955; Glock and McLean, 1957) in tumour tissues calls for special attention. It appears that since adenine is a constituent of nucleic acids and also of pyridine nucleotides, any drain on this precursor from the metabolic pool in the nucleic acid synthesis of tumour may deprive the host tissues of its availability for pyridine nucleotide synthesis. Our own findings on levels of activity of the choline-dehydrogenase in the livers of tumour-bearing animals were considerably lower than those observed in the tissues of normal animals. It was further shown that this inherently diminished enzyme activity could be reversed by fortification of the medium with DPN. In the present communication two problems have been investigated: (i) the influence of the tumour on the host tissues with respect to the pyridine nucleotide levels and (ii) the availability or non-availability of adenine nucleotides in the synthesis of pyridine nucleotides in host tissues. For this purpose, two types of transplantable tumours: (a) fast growing ascites Yoshida sarcoma and (b) comparatively slow growing fibrosarcoma have been used in Wistar rats and Swiss mice respectively. M

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