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Two novel 3,4-seco-trinorlanostane triterpenoids isolated fromGanoderma fornicatum

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
45
Issue
14
Identifiers
DOI: 10.1016/j.tetlet.2004.02.056
Keywords
  • Ganoderma Fornicatum
  • Ganodermataceae
  • Trinorlanostane
  • Fornicatins A And B
  • Nmr
  • X-Ray
Disciplines
  • Chemistry

Abstract

Two novel 3,4- seco-25,26,27-trinorlanostane triterpenoid compounds, fornicatins A and B ( 1 and 2 ) have been isolated from the fruiting body of Ganoderma fornicatum. The structural elucidation of 1 and 2 were accomplished by extensive NMR analysis. The relative stereochemistry of 2 was established by single crystal X-ray crystallography, which also confirmed the novel carbon skeleton of the new triterpenoid. An ether linkage of C-4 with C-7 in 1 is unprecedented in natural triterpenoids. Both compounds were tested for their inhibitory effects on rabbit platelet aggregation induced by PAF, ADP, or AA.

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