Ibrahiem Saeed Abdul-Rahman1, Ali M. Al-Amri2 and Khalid Qassim Ghallab31Associate Professor, Internal Medicine/Nephrology. 2Assistant Professor/Internal Medicine/Oncology. 3Demonstrator, Department of Pathology, King Fahd Hospital of the University, King Faisal University, Saudi Arabia. AbstractCastleman’s disease (CD) is a group of rare lymphoproliferative disorders sharing characteristic clinical and histological features, and usually accompanied by a marked systemic inflammatory response. Three histological patterns of lymph nodes were described: the hyaline-vascular, the plasma-cell and the mixed types. The former is more common (80%–90%) and tends to be localized. The plasma cell type is more aggressive and usually multicentric. It is interesting that the inflammatory manifestations seem to be related to a lymph node lesion, because the systemic symptoms and inflammatory activity can return to normal after surgical excision or successful medical treatment of the disease. We report here our 15-year experience with this rare disease in King Fahd Hospital of the University, Al-Khobar, Saudi Arabia, focusing on the clinical features, therapy, and patients’outcome.