Abstract The effect of livingstone potato (Plectranthus esculenthus N.E.Br) on serum glucose, glycated hemoglobin (HbA1C), serum triglyceride, total cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL), very low density lipoprotein (VLDL), hepatic malic enzyme (ME), isocitrate dehydrogenase (IDH) and catalase activities of Streptozotocin induced diabetic rats were investigated using standard techniques. The atherogenic index (AI) and coronary risk index (CRI) of the rats were calculated as the ratios of LDL to HDL and total cholesterol to HDL, respectively. The serum glucose of the non-diabetic, diabetic control and diabetic rats given livingstone potato incorporated feeds (test feed) were 92.58±3.97, 352.30±4.88 and 165.50±7.88mg/dl, respectively. Intake of the test feed by the diabetic rats of group 3, resulted in significant (P<0.05) decrease of their serum glucose, HbA1c, triglyceride, cholesterol, LDL, VLDL, AI and CRI but significant increase (P<0.05) of hepatic levels of ME, IDH, catalase and serum HDL compared with the diabetic control rats that had significant alteration of these parameters (P<0.05) compared with the non-diabetic rats. The feed intakes of the non-diabetic, diabetic control and diabetic rats given the test feed were 133.34±1.32, 137.84±5.77 and 146.38±4.33g/rat/week by the last week of experimentation. The diabetic control rats recorded significant loss of weight (P<0.05) compared with the non diabetic rats despite increased feed intake. Chemical analysis of the standard and test feeds showed that the standard rat feed contained 15.00±0.78% protein, 7.24±1.20% fat, 31.55±2.62% carbohydrates, energy value of 290.65±4.77kcal/100g, 10% crude fiber and 0.12±0.04mg Gallic Acid Equivalent while the test feed contained 40.10±0.16% carbohydrates, 17.22±0.40% protein, 22.16±0.34% fat, energy value of 428.70±2.12kcal/100g, 8.51±0.16% crude fiber, 1.3±0.2mg Gallic Acid Equivalent/g of sample and strong antioxidant activity comparable to standard quercetin. The study shows the potentials of livingstone potato in the management of diabetes and hyperlipidemia.