Affordable Access

Publisher Website

Endothelium-dependent vasorelaxant effects of the essential oil from aerial parts ofAlpinia zerumbetand its main constituent 1,8-cineole in rats

Authors
Journal
Phytomedicine
0944-7113
Publisher
Elsevier
Publication Date
Volume
16
Issue
12
Identifiers
DOI: 10.1016/j.phymed.2009.04.007
Keywords
  • Alpinia Zerumbet
  • 1
  • 8-Cineole
  • Essential Oil
  • Isolated Thoracic Aorta
  • Nitric Oxide

Abstract

Abstract Vasorelaxant effects of essential oil of Alpinia zerumbet (EOAZ) and its main constituent, 1,8-cineole (CIN) were studied. In rat isolated aorta preparations with intact endothelium, EOAZ (0.01–3000 μg/ml) induced significant but incomplete relaxation of the phenylephrine-induced contraction, an effect that was abolished by removal of vascular endothelium. However, at the same concentrations (0.01–3000 μg/ml corresponding to 0.0000647–19.5 mM), CIN induced a complete vasorelaxant effects (IC 50=663.2±63.8 μg/ml) that were significantly reduced in endothelium-denuded rings (IC 50=1620.6±35.7 μg/ml). Neither EOAZ nor CIN affected the basal tonus of isolated aorta. Vasorelaxant effects of both EOAZ and CIN remained unaffected by the addition of tetraethylamonium chloride (500 μM) or indomethacin (10 μM) into the bath, but were significantly reduced by N G-nitro-L-arginine methyl ester (100 μM). It is concluded that EOAZ induces a potent vasorelaxant effect that could not be fully attributed to the actions of the main constituent CIN, and appears totally dependent on the integrity of a functional vascular endothelium. The data is novel and corroborate the popular use of A. zerumbet for the treatment of hypertension.

There are no comments yet on this publication. Be the first to share your thoughts.