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Inactivation of basal glycogen synthase by glucagon and epinephrine in hepatocytes from fed rats

Authors
Journal
FEBS Letters
0014-5793
Publisher
Wiley Blackwell (John Wiley & Sons)
Publication Date
Volume
200
Issue
1
Identifiers
DOI: 10.1016/0014-5793(86)80508-7
Keywords
  • (Rat Hepatocyte)Glucagonepinephrineglycogen Synthase
Disciplines
  • Biology

Abstract

Abstract Glucagon and epinephrine promote the inactivation of basal glycogen synthase in hepatocytes isolated from fed rats. However, this effect is only observable when the activation state of glycogen synthase is measured using the low glucose-6-P/high glucose-6-P activity ratio assay. This inactivation is the consequence of an increase in the kinetic parameters ( S 0.5 for UDP-glucose and M 0.5 for glucose-6-P) of the enzyme. Therefore, this work demonstrates these hormones are also able to control glycogen synthase from fed animals.

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