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Enantioselective esterification of racemic ibuprofen in isooctane by immobilized lipase on cellulose acetate-titanium iso-propoxide gel fiber

Authors
Publisher
Elsevier B.V.
Publication Date
Volume
93
Issue
1
Identifiers
DOI: 10.1016/s1389-1723(02)80062-7
Keywords
  • Candida Rugosa
  • Enantioselective Esterification
  • Entrap-Immobilization
  • Fiber
  • Ibuprofen

Abstract

Abstract Lipase ( Candida rugosa) was entrap-immobilized on cellulose acetate-titanium iso-propoxide gel fiber by the sol-gel method. The immobilized lipase was used for the direct synthesis of ( S)-ibuprofen ester from racemic ibuprofen using propyl alcohol as an acyl acceptor in isooctane. The activity of the immobilized lipase was decreased to about 10–20% that of native lipase. However, the reaction was more enantioselective compared to that with native lipase. The stability for repeated use was improved by immobilization.

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