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Calcium Liberates PNAs from Endosomes

Authors
Journal
Chemistry & Biology
1074-5521
Publisher
Elsevier
Publication Date
Volume
12
Issue
8
Identifiers
DOI: 10.1016/j.chembiol.2005.08.003

Abstract

Many peptides are reported to enhance cellular uptake of peptide nucleic acids and other macromolecules. Cellular uptake, however, is not synonymous with cellular activity. In this issue of Chemistry & Biology, Nielsen and colleagues [ 1] examine the traffic of PNAs and investigate protocols for improving recognition of target mRNA inside cells.

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