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Enantioselective synthesis of siloxycyclopropanes and of ???-oxocarboxylates by asymmetric catalysis

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
30
Issue
16
Identifiers
DOI: 10.1016/s0040-4039(01)93716-5

Abstract

Abstract Up to 48% enantiomeric excess have been attained by cyclopropanation of silyl enol ethers with methyl diazoacetate in the presence of optically active Cu-catalysts. Subsequent ring opening of resulting siloxycylopropanes gives ???-oxocarboxylates with a maximum enantiomeric excess of 37%.

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