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Studies on the Chemical Nature of the Substance Inducing Transformation of Pneumococcal Types: III. An Improved Method for the Isolation of the Transforming Substance and Its Application to Pneumococcus Types II, III, and VI

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Rockefeller University Press
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Abstract

In this second of two direct follow-ups to the 1944 paper on the Transforming Principle, Avery and McCarty provided further details of experimentation which showed that citrate (a salt or ester of citric acid) acted as a powerful inhibitor of enzymatic action on DNA, thus resulting in high yields of transforming DNA during experiments. Later, McCarty wrote that when one considered the combined data of the three papers, "there was not much room left for the skeptics to advance sensible alternatives to the view that DNA was the active substance in transformation."

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