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Stimulation of rat liver 4-hydroxybenzoate: polyprenyl transferase activity by a cytosolic protein factor; Evidence for a polyprenyl pyrophosphate transport protein

Authors
Journal
Biochemical and Biophysical Research Communications
0006-291X
Publisher
Elsevier
Publication Date
Volume
119
Issue
3
Identifiers
DOI: 10.1016/0006-291x(84)90889-1
Disciplines
  • Biology

Abstract

Abstract Rat liver postmicrosomal supernatant contains a factor which stimulates the 4-hydroxybenzoate:polyprenyl transferase activity of whole mitochondria and inner mitochondrial membrane fragments. The factor involved appears to be a heat stable, nondializable protein sensitive to tryptic hydrolysis and has been partially purified. Since this protein binds nonaprenyl pyrophosphate and stimulates its transport into mitochondria but shows no similar effect with 4-hydroxybenzoate, it is suggested that this protein also acts as an all trans polyprenyl pyrophosphate carrier protein.

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