Affordable Access

Publisher Website

Synthesis and neuromuscular blocking activity of 16-(2- and 3-pyridylmethylene) dehydroepiandrosterone derivatives

Authors
Journal
Steroids
0039-128X
Publisher
Elsevier
Publication Date
Volume
75
Identifiers
DOI: 10.1016/j.steroids.2010.01.009
Keywords
  • Neuromuscular Blockers
  • Quaternary Ammonium Compounds
  • Depolarizing Competitive Antagonism
  • In Vitroandin Vivomodels

Abstract

Abstract The interonium distance plays a major role in neuromuscular blocking activity of bis-quaternary ammonium compounds. In this study we tried to alter the distance between two quaternary nitrogens in some of the steroidal derivatives synthesized and evaluated them for neuromuscular blocking activity using in vivo (in chicks) and in vitro models (rectus abdominus and chick biventer cervis muscle) for their mechanism of action. All the synthesized compounds have shown to possess good depolarizing, competitive neuromuscular blocking activity, particularly the 17-acetoxy derivative and the increase in the distance between two quaternary nitrogens decreased the activity.

There are no comments yet on this publication. Be the first to share your thoughts.