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Decreased susceptibility of red blood cells to lipid peroxidation in patients with alcoholic liver cirrhosis

Authors
Journal
Clinica Chimica Acta
0009-8981
Publisher
Elsevier
Publication Date
Volume
145
Issue
3
Identifiers
DOI: 10.1016/0009-8981(85)90035-x
Keywords
  • Lipid Peroxidation
  • Hemolysis
  • Alcoholism
  • Alcoholic Liver Cirrhosis
Disciplines
  • Medicine

Abstract

Abstract Red blood cells from alcoholics with and without liver cirrhosis and control subjects were examined for the susceptibility to lipid peroxidation. Red blood cells of patients with liver cirrhosis were found to be less sensitive to hydrogen peroxideinduced peroxidation measured by a new, reliable and sensitive method: the release of pentane during red blood cell lipid peroxidation. Changes of sensitivity to lipid peroxidation correlated with the severity of the liver malfunction, but not with abnormalities of the lipid composition of red cell membranes which are apparent in patients with liver disease. In alcoholics without liver cirrhosis, only minor changes in the susceptibility of red cells to peroxidation were observed.

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