Affordable Access

Publisher Website

Bone marrow transplantation in a holstein heifer withbovine leucocyte adhesion deficiency

Authors
Journal
The Veterinary Journal
1090-0233
Publisher
Elsevier
Publication Date
Volume
156
Issue
1
Identifiers
DOI: 10.1016/s1090-0233(98)80056-7
Keywords
  • Blad
  • Bone Marrow Transplantation
  • Monitor
  • Cd18-Positive Cells
Disciplines
  • Medicine

Abstract

Summary Bone marrow transplantation (BMT) was performed in a 9-month-old heifer with bovine leucocyte adhesion deficiency (BLAD). Clinical and haematological findings, selected neutrophil function and CD18 expression of neutrophils in a B 2 integrin-deficient heifer were examined. Twelve months after BMT, a small fluorescent region in the CD18-positive area of a flow cytometric profile was demonstrated and estimated to represent 0.3–0.5% of the CD18-positive neutrophils as measured by flow cytometric analysis following immunomagnetic separation. The animal's clinical condition appeared to improve and stabilize over our observation period of 28 months following BMT. Newly expressed CD 18 seemed to play an important role in ameliorating the clinical signs of BLAD in this heifer.

There are no comments yet on this publication. Be the first to share your thoughts.